Add Kittle to the list of injuries piling up for the 49ers ahead of Week 3. With Christian McCaffrey already on IR and Deebo Samuel likely to miss a few weeks with his own injury, Brock Purdy could potentially face Week 3 with three of his four Avengers on offense out of commission. Fantasy managers should look to the waiver wire for a potential backup tight end should he ultimately be ruled out, but considering the timing of the injury and finicky nature of hamstrings, it wouldn’t be a surprise to see Kittle sidelined this weekend. With a great matchup against the Rams’ secondary and Tre’Davious White, WR Brandon Aiyuk is a must-start in all formats with most, if not all of his significant target competition either already out or questionable. Brock Purdy could slide in the rankings a bit after getting off to a slow start through two weeks, especially with his offensive arsenal seemingly dwindling by the day.